| Item Type | Name |
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Academic Article
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Comparative analysis of the expression and oncogenic activities of Xenopus c-, N-, and L-myc homologs.
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Academic Article
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Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice.
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Academic Article
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A genetic screen for candidate tumor suppressors identifies REST.
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Academic Article
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Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.
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Concept
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Tumor Cells, Cultured
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Concept
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Cells, Cultured
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Academic Article
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Complex transcriptional regulation of myc family gene expression in the developing mouse brain and liver.
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Academic Article
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Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1.
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Academic Article
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Analysis of C-MYC function in normal cells via conditional gene-targeted mutation.
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Academic Article
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Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions.
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Academic Article
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Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.
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Academic Article
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Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.
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Academic Article
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The LKB1 tumor suppressor negatively regulates mTOR signaling.
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Academic Article
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Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production.
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Academic Article
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Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1.
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Academic Article
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Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism.
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Academic Article
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Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes.
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Academic Article
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FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis.
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Academic Article
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Endothelial FoxO1 is an intrinsic regulator of thrombospondin 1 expression that restrains angiogenesis in ischemic muscle.
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Academic Article
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Instability of immunoglobulin genes in S107 cell line.
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Academic Article
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ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF.
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Academic Article
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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus.
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Academic Article
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Overexpression of Mad transcription factor inhibits proliferation of cultured human hepatocellular carcinoma cells along with tumor formation in immunodeficient animals.
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Academic Article
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Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.
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Academic Article
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p16(INK4a) and p53 deficiency cooperate in tumorigenesis.
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Academic Article
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Genetic determinants of malignancy in a mouse model for oligodendroglioma.
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Academic Article
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mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells.
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Academic Article
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Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma.
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Academic Article
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Molecular diversity of astrocytes with implications for neurological disorders.
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Academic Article
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Essential role of limiting telomeres in the pathogenesis of Werner syndrome.
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Academic Article
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Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation.
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Academic Article
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Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16.
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Academic Article
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FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice.
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Academic Article
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FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts.
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Academic Article
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Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis.
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Academic Article
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Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor.
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Academic Article
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FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress.
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Academic Article
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Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification.
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Academic Article
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AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.
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Academic Article
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Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction.
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Academic Article
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The human myc gene family: structure and activity of L-myc and an L-myc pseudogene.
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Academic Article
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Effects of the MYC oncogene antagonist, MAD, on proliferation, cell cycling and the malignant phenotype of human brain tumour cells.
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Academic Article
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Inhibition of ras-induced proliferation and cellular transformation by p16INK4.
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Academic Article
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Role of first exon/intron sequences in the regulation of myc family oncogenic potency.
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Academic Article
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Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype.
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Academic Article
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Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation.
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Academic Article
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Telomere-dependent senescence.
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Academic Article
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Essential role for oncogenic Ras in tumour maintenance.
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Academic Article
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Use of the human EF-1alpha promoter for expression can significantly increase success in establishing stable cell lines with consistent expression: a study using the tetracycline-inducible system in human cancer cells.
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Academic Article
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p16(Ink4a) in melanocyte senescence and differentiation.
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Academic Article
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Connecting chromosomes, crisis, and cancer.
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Academic Article
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Telomerase extracurricular activities.
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Academic Article
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Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.
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Academic Article
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mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival.
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Academic Article
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Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization.
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Academic Article
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Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy.
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Academic Article
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FoxO4 regulates tumor necrosis factor alpha-directed smooth muscle cell migration by activating matrix metalloproteinase 9 gene transcription.
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Academic Article
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The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis.
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Academic Article
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Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver.
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Academic Article
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LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis.
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Academic Article
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Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling.
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Academic Article
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Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress.
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Academic Article
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Foxo1 integrates insulin signaling with mitochondrial function in the liver.
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Academic Article
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FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis.
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Academic Article
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Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.
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Academic Article
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FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis.
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Academic Article
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From the Cover: Neutralization of terminal differentiation in gliomagenesis.
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Academic Article
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Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.
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Academic Article
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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA.
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Academic Article
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Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit.
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Academic Article
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STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation.
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Academic Article
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Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma.
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Academic Article
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Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells.
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Academic Article
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Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway.
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Academic Article
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The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis.
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Academic Article
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PCAF modulates PTEN activity.
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Academic Article
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FOXO1 in the ventromedial hypothalamus regulates energy balance.
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Academic Article
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Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240.
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Academic Article
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FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin.
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Academic Article
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ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma.
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Academic Article
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FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis.
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Academic Article
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FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis.
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